The University of Arizona

MIC 519/419H

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Welcome to MIC 519/419H!

Immunology is the study of the body's natural defenses against infectious disease. These pages provide resources for MIC 519/419H, an introductory immunology course for graduate students and honors undergraduate students at the University of Arizona. The goals of MIC 519/419H are to familiarize you with basic knowledge of the immune system and promote continued learning by studying the current immunology research literature and techniques. If you are interested in the regular undergraduate section of this course, see MIC 419.

Instructor 

Dr. Jan Decker   Senior Lecturer, Veterinary Science and Microbiology
Room 235, Vet Sci & Micro   Phone: 621-8942   Email: jdecker@u.arizona.edu.
Office Hours: http://microvet.arizona.edu/Courses/MIC419/mic419instructor.html

ANNOUNCEMENTS

Exam 2 now available

Dr. Akporiaye's powerpoint.

Proposals for Review

Pink sheets (individual reviews of the proposals) are due in class Tuesday November 27. Bring two copies, one with your name for grading and one without your name to be given to the authoring team. Class time is available on Tuesday November 27 for discussing the pink sheets and revising your proposals, as well as evaluating your team members for participation. Class attendance is required.

Graded Midterm exams will be available in class Tuesday November 27. Grades are posted on D2L; please check for accuracy.

Calendar 2007
TR 3:30-5:30 PM  CHAVEZ 304
Calendar subject to change during the semester

Date
Topic
Reading
Proposal Due Dates
T Aug 21
Introduction and Course Overview; Case 1
Immunity Rules: Basic Concepts in Immunology
Schedule, Syllabus
R Aug 23
Paper 1 Vesikari, T., et al. 2006. Safety and efficacy of a pentavelent human-bovine (WC3) reassortment Rotavirus vaccine . The New England Journal of Medicine 354: 23-33 (January 5)
Ch 1; Paper 1
T Aug 28
Innate Immune Recognition and Pathogen Elimination
Case 2 ; Team formation
Ch 2
R Aug 30
Proposal
Proposal: Team Organization
T Sept 4
Antigen Recognition by B-cell and T-cell Receptors Case 3  

Ch 3

R Sept 6
Paper 2:Maddipatla, S. et al. Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20. Clinical Cancer Research 13:4556-4564, August 1, 2007.
Paper 2
T Sept 11
4:30 PM TODAY ONLY Generation of Antigen-Specific B and T Cells - Activity, Case 4
Ch 4
R Sept 13

Proposal
Proposal: Pathogen and Antigens
T Sept 18
Antigen Presentation to T Lymphocytes Case 5
Ch 5
R Sept 20
Paper 3: Chen, X. et al. Distinct endosomal trafficking requirememnts for presentation of autoantigens and exogenous lipids by human CD1d molecules. J. Immunology (2007) 178: 6181-6190.
Paper 3
T Sept 25
T Cell-Mediated Immunity Case 6
Ch 8
R Sept 27
Proposal
Proposal: Vaccine type
Exit Ticket 3
Evaluations
T Oct 2
Humoral Immune Response Case 7
Ch 9
R Oct 4
Paper 4: Lönard, B. M. et al., Estimation of Human herpesvirus 8 prevalence in high-risk patients by analysis of humoral and cellular immunity. Transplantation 84(1): 40-45 July 15, 2007. See also Toolbox ELISA, Flow Cytometry, Antigen Binding Tetramer MHC Peptide, ELISPOT

Paper 4
T Oct 9
Immunity to Infectious Disease Case 8
Exam 1 (Case 9) available on line
Ch 10
R Oct 11
Proposal
Proposal: Immune Responses
T Oct 16
Case 9 = MIDTERM EXAM (no class)
Ch 1-5, 8-10
R Oct 18
Proposal in-class session: come with your questions about vacines in gneral and your vaccine in particular.
Ch 11
T Oct 23
Exam 1 due by 3:30 PM in VSM 235 and to turnitin.com
No class
Paper 5
R Oct 25
Proposal
Proposal: Assessment
T Oct 30
Allergy and Hypersensitivity Case 10
Ch 12
R Nov 1
Paper 6: Tsuji, N. M. et al. Interleukin-10-secreting Peyers Patch cells are responsible for active suppression in low-dose oral tolerance. Immunology (2001) 103: 458-464.
Paper 6
T Nov 6
Development of the Immune System and Autoimmunity Case 11
Ch 7 and 13
R Nov 8
Proposal
Proposal: Assembly and Proofreading
T Nov 13
HIV and AIDS: Dr. Ahmad, MBIM
Ch 11
R Nov 15
No class
Proposal(Submit for online posting by Friday 11/16 9AM )
---
T Nov 20
Proposal: Study Sections
Proposal: Peer Review
R Nov 22
Thanksgiving Holiday
***
T Nov 27
Course Evaluation, Peer Evaluations
Proposal Individual Pink Sheets will be exchanged IN CLASS
Proposal: response to Peer Review
R Nov 29
No class
Exam 2 now available
Ch 14
T Dec 4

Tumor Immunology, Dr. Akporiaye
Proposal Due in class

T Dec 11
 Exam 2 due in Dr. Decker's office and at turnitin.com

* Text = Janeway et al. Immunobiology The Immune System in Health and Disease, 6th edition, 2005. Case studies and research paper readings will be assigned by the instructor the week before the date they are discussed.

** All papers accessible through Arizona Health Sciences Library electronic site http://www.ahsl.arizona.edu

Go to the Arizona Health Sciences Library (AHSL) at http://www.ahsl.arizona.edu/
Click on Journals in the top menu bar
Click on N in the Electronic Journals box (for New England Journal of Medicine)
Scroll down to the journal name and click on the link (where there are two choices, choose the top one)
Click on GO
If you are off campus, enter your Cat Card number and click SUBMIT. If you are on campus, you will go directly to the journal.

Drop deadlines: no grade 9/14; with a W 10/12; complete withdrawal, 12/5

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http://microvet.arizona.edu/Courses/VSC519/vsc519index.html
© 2001    Copying allowed for educational purposes only
Written by Janet M. Decker, PhD       jdecker@u.arizona.edu
Last modified December 5, 2007