The University of Arizona

Lisa Shubitz

Lisa Schubitz
 
BS in Animal Health Science, University of Arizona
Doctor of Veterinary Medicine, Colorado State University
Associate Research Professor
 
Department of Veterinary Science and Microbiology
University of Arizona 
Tucson, AZ 85721
Phone (520) 626-8198
Fax (520) 621-6366
Email lfshubit@u.arizona.edu
 
Research interests
 
Our research involves the locally endemic systemic fungal infection, coccidioidomycosis, known in lay terms as Valley Fever.  Valley Fever is acquired by inhaling the spores from the air and dust in Arizona’s deserts and most commonly causes pneumonia in people and dogs.  However, it can spread to other parts of the body and cause very severe, even fatal, disease.  With the Valley Fever Center for Excellence, we do research on vaccine development, new antifungal drugs to treat Valley Fever, and immunology to help understand the disease. 
 
Coccidioides species, the fungi that cause Valley Fever, are Select Agents and also are Biosafety Level 3 pathogens.  Dr. Shubitz is director of a Biosafety Level 3 laboratory, which contains special equipment to keep personnel from becoming ill while working with the live Valley Fever agent.  In the last two years, testing of a new drug, Nikkomycin Z, has been going on in the laboratory, and now is in a preclinical trial in naturally infected dogs.
 
In addition to laboratory research, Dr. Shubitz is interested in clinical research in dogs regarding better treatments and understanding immunology in dogs with severe disease.  Tucson is a great laboratory for dogs with Valley Fever and we can learn a lot from sick dogs.
 
Outreach/Clinical
 
Dr. Shubitz provides educational seminars on Valley Fever in dogs within the communities of Tucson and Phoenix and consults on canine Valley Fever cases one afternoon a week at Veterinary Specialty Center of Tucson. 
 
Selected publications
 
 
 
Shubitz LF, SM Dial, R Perrill, R Casement, JN Galgiani.  Vaccine-induced cellular immune responses differ from innate responses in susceptible and resistant strains of mice infected with Coccidioides posadasii.  Inf Immun  2008, 76(12): 5553-64. PMID: 18852250
 
Graupmann-Kuzma A, BA Valentine, LF Shubitz, SM Dial, B Watrous, SJ Tornquist.  Coccidioidomycosis in dogs and cats: A review. J Am An Hosp Assoc 2008, 4 4(5):226-235. PMID: 18762558
 
Shubitz, LF. Comparative aspects of coccidioidomycosis in animals and humans. Annals of New York Academy of Sciences 2007, 1111: 395-403. PMID: 17332082
 
Shubitz, LF, JN Galgiani, ZQ Tian, Z Zhong, P Timmermans, L Katz. Efficacy of ambruticin analogs in a murine model of coccidioidomycosis. Antimicrobial Agents and Chemotherapy 2006, 50(10):3467-69. PMID: 17005834
 
Shubitz, LF, J Yu, CY Hung, TN Kirkland, T Peng, R Perrill, J Simons, J Xue, RA Herr, GT Cole, JN Galgiani. Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein.  Vaccine 2006, 24(31-32):5904-11. PMID: 16759762 
 
Orsborn, KI, LF Shubitz, T Peng, EM Kellner, MJ Orbach, PA Haynes, JN Galgiani. Protein expression of Coccidioides posadasii by two-dimensional in-gel electrophoresis and evaluation of a newly recognized peroxisomal matrix protein as a recombinant vaccine candidate. Inf and Immunity 2006, Vol. 74(3): 1865-1872. PMID: 16495561
 
Shubitz, LF and SM Dial. Coccidioidomycosis: a diagnostic challenge. Clin Tech in Sm An Practice 2005, Vol. 20(4):220-226. PMID:16317911
 
Shubitz, LF, CD Butkiewicz, SM Dial, CP Lindan. Incidence of Coccidioides infection among dogs residing in a region in which the organism is endemic. JAVMA 2005, Vol 226(11):1846-1850. PMID: 15938056
 
Butkiewicz, CD, LF Shubitz, SM Dial.  Risk factors associated with Coccidioides infection in dogs. JAVMA 2005, Vol 226(11):1851-1854. PMID: 15938057
 
Peng T, Shubitz L, Simons J, Perrill R, Orsborn KI, Galgiani JN.  Localization within a proline-rich antigen (Ag2/PRA) of protective antigenicity against infection with Coccidioides immitis in mice.  Infect Immun 2002; 70(7):3330-3335. PMID: 12065470
 
Shubitz, L, T Peng, R Perrill, J Simons, K Orsborn, JN Galgiani. Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA. Infect Immun 2002; 70(6):3287-3289. PMID: 12011027
 
Shubitz, LF, ME Matz, TH Noon, GA Bradley, CC Reggiardo. Constrictive pericarditis secondary to Coccidioides immitis infection in a dog. 2001 J Am Vet Med Assoc, Vol 218(4):537-540. PMID: 11229504
 
Abuodeh RO, LF Shubitz, E Siegel, S Snyder, T Peng, KI Orsborn et al. Resistance to Coccidioides immitis in mice after immunization with recombinant protein or DNA vaccine of a proline-rich antigen. Infect Immun 1999; 67(6):2935-2940. PMID: 10338502